Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, Beth Levine, Ana María Cuervo et al. · Nature · 2008 · 6.4K citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark et al. · Journal of Biological Chemistry · 2007 · 4.5K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

James Palacino, Dijana Šagi, Matthew S. Goldberg et al. · Journal of Biological Chemistry · 2004 · 998 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

Wei Li, Mário Henrique Bengtson, Axel Ulbrich et al. · PLoS ONE · 2008 · 840 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Structure of a c-Cbl–UbcH7 Complex

Ning Zheng, Ping Wang, Philip D. Jeffrey et al. · Cell · 2000 · 832 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11