Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction

R.P. Hegde, Srinivasa M. Srinivasula, Zhijia Zhang, +8

Journal of Biological Chemistry

Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

Anupama Kotha, Madhavi Sekharam, Lucia Cilenti, +6

Molecular Cancer Therapeutics

Chemoprevention StrategyLipid PeroxidationApoptosisCell DeathCancer Biology +19

Acute renal failure in zebrafish: a novel system to study a complex disease

Dirk M. Hentschel, Kwon Moo Park, Lucia Cilenti, +3

American Journal of Physiology-Renal Physiology

Renal PathologyImmunologyRenal InflammationCell DeathGlomerulonephritis +18

Regulation of HAX-1 Anti-apoptotic Protein by Omi/HtrA2 Protease during Cell Death

Lucia Cilenti, Mangala M. Soundarapandian, George A. Kyriazis, +6

Journal of Biological Chemistry

Characterization of a Novel and Specific Inhibitor for the Pro-apoptotic Protease Omi/HtrA2

Lucia Cilenti, Younghee Lee, Sibylle Hess, +7

Journal of Biological Chemistry

Omi/HtrA2 Promotes Cell Death by Binding and Degrading the Anti-apoptotic Protein ped/pea-15

Alessandra Trencia, Francesca Fiory, Maria Alessandra Maitan, +10

Journal of Biological Chemistry

Ped/pea-15 DegradationMitophagyApoptosisImmunologyCell Death +15

Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP

Camilla T. Ambivero, Lucia Cilenti, Stacey Main, +1

Cellular Signalling

MitophagyProtein FunctionNatural SciencesGeneticsAutophagy +6

Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells

Lucia Cilenti, George A. Kyriazis, Mangala M. Soundarapandian, +7

American Journal of Physiology-Renal Physiology

UrologyMitochondrial FunctionKidney ResearchMedicineApoptosis +10

The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion

Jürgen Althaus, Markus D. Siegelin, Faramarz Dehghani, +3

Neurochemistry International

Focal Cerebral Ischemia/reperfusionCerebral Vascular RegulationNeurophysiologyCell DeathXiap Cleavage +13

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy

Lucia Cilenti, Camilla T. Ambivero, Nathan P. Ward, +3

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

MitophagyMitochondrial FunctionMedicineGeneticsAutophagy +7