Redefining the TGR5 Triterpenoid Binding Pocket at the C‐3 Position

Abstract

A defining characteristic: Syntheses of potent TGR5 agonists were used to characterize binding interactions. A serie of C-3 modified betulinic acid derivatives were synthesized and evaluated. Among them, epoxide 15 showed nanomolar activity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.