Site-specific insulin conjugates with enhanced stability and extended action profile

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

New England Journal of Medicine · 1993 · 24.7K citations · Full text

Medicine, Endocrinology, Internal Medicine +14

Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.

Abraham Abuchowski, T. van Es, Nicholas C. Palczuk et al. · Journal of Biological Chemistry · 1977 · 1.4K citations · Full text

Life Sciences, Biochemistry, Clinical Biochemistry +7

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

Abraham Abuchowski, Judy McCoy, Nicholas C. Palczuk et al. · Journal of Biological Chemistry · 1977 · 1.3K citations · Full text

Life Sciences, Biochemistry, Immunology +14

The structure of 2Zn pig insulin crystals at 1.5 Å resolution

Edward N. Baker, T.L. Blundell, J.F. Cutfield · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1988 · 673 citations

Life Sciences, Biochemistry, Biophysics +17

Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.

Victoria Sluzky, J A Tamada, Alexander M. Klibanov et al. · Proceedings of the National Academy of Sciences · 1991 · 518 citations

Natural Sciences, Biochemistry, Chemistry +15