Water-soluble poly-(l-glutamic acid)–Gly-camptothecin conjugates enhance camptothecin stability and efficacy in vivo

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee.

P. Vasey, Stan B. Kaye, Rachel Morrison et al. · PubMed · 1999 · 691 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Differential Interactions of Camptothecin Lactone and Carboxylate Forms with Human Blood Components

Zihou Mi, Thomas G. Burke · Biochemistry · 1994 · 297 citations

Medicine, Biochemistry, Pharmacology +8

Marked Interspecies Variations Concerning the Interactions of Camptothecin with Serum Albumins: A Frequency-Domain Fluorescence Spectroscopic Study

Zihou Mi, Thomas G. Burke · Biochemistry · 1994 · 139 citations

Medicine, Biochemistry, Pharmacology +15

Conjugation of Camptothecins to Poly‐(l‐Glutamic Acid)

Jack W. Singer, Peter de Vries, Rama Bhatt et al. · Annals of the New York Academy of Sciences · 2000 · 66 citations

Pharmacy, Pharmaceutics, Pharmacology +16