Chronic NF-κB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text

Medicine, Cell Biology, Oncology +10

A DNA damage checkpoint response in telomere-initiated senescence

Fabrizio d’Adda di Fagagna, Philip M. Reaper, Lorena Clay-Farrace et al. · Nature · 2003 · 2.8K citations

Life Sciences, Cell Biology, Molecular Biology +14

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos et al. · Nature · 2006 · 2K citations

Medicine, Cancer Biology, Oncology +16

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Raffaella Di Micco, Marzia Fumagalli, Angelo Cicalese et al. · Nature · 2006 · 1.8K citations

Medicine, Molecular Biology, Oncology +16

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Christian Beauséjour, Ana Krtolica, Francesco Galimi et al. · The EMBO Journal · 2003 · 1.4K citations · Full text

Life Sciences, Molecular Biology, Oncology +14