Concepedia

Adeno-associated viral delivery of a metabolically regulated insulin transgene to hepatocytes

Mirosław Kozłowski, Darin E. Olson, Janet Rubin, Dorota Lyszkowicz, Adam G. Campbell, Peter M. Thulé

Molecular and Cellular Endocrinology · 2007 · 15 citations · 48 references

DOI

Concepts

References

48

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Catherine S. Manno, Glenn F. Pierce, Valder R. Arruda et al. · Nature Medicine · 2006 · 2.1K citations

, , +9

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

Yang Yang, Frederick A. Nunes, Klára Berencsi et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations

, , +15

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

F K Ferrari, T. V. Samulski, Thomas Shenk et al. · Journal of Virology · 1996 · 762 citations · Full text

, , +14

Novel Tools for Production and Purification of Recombinant Adenoassociated Virus Vectors

Dirk Grimm, Andrea Kern, Karola Rittner et al. · Human Gene Therapy · 1998 · 700 citations

, , +16

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

Richard O. Snyder, Carol H. Miao, G. Patijn et al. · Nature Genetics · 1997 · 585 citations

, , +13