Pharmacophore modeling for hERG channel facilitation

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Medicine, Cardiology, Molecular Genetics +16

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

Matthew C. Trudeau, Jeffrey W. Warmke, Barry Ganetzky et al. · Science · 1995 · 1.2K citations

Natural Sciences, Genetics, Molecular Genetics +17

A structural basis for drug-induced long QT syndrome

John S. Mitcheson, Jun Chen, Monica Lin et al. · Proceedings of the National Academy of Sciences · 2000 · 937 citations

Medicine, Cardiology, Pharmacology +17

Toward a Pharmacophore for Drugs Inducing the Long QT Syndrome:  Insights from a CoMFA Study of HERG K⁺ Channel Blockers

Andrea Cavalli, Elisabetta Poluzzi, Fabrizio De Ponti et al. · Journal of Medicinal Chemistry · 2002 · 385 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Physicochemical Features of the hERG Channel Drug Binding Site

David Fernández, Azad Ghanta, Gregory W. Kauffman et al. · Journal of Biological Chemistry · 2004 · 265 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16