Concepedia

Predictive and Prognostic Roles of <i>BRAF</i> Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803

Shuji Ogino, Kaori Shima, Jeffrey A. Meyerhardt, Nadine J. McCleary, Kimmie Ng, Donna Hollis, Leonard B. Saltz, Robert J. Mayer, Paul Schaefer, Renaud Whittom,

Clinical Cancer Research · 2011 · 266 citations · 40 references

DOIFull text

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Abstract

BRAF mutation is associated with inferior survival in stage III colon cancer. Additional studies are necessary to assess whether there is any predictive role of BRAF mutation for irinotecan-based therapy.

References

40

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

Daniel J. Weisenberger, Kimberly D. Siegmund, Mihaela Campan et al. · Nature Genetics · 2006 · 2K citations

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Prognostic Role of <i>KRAS</i> and <i>BRAF</i> in Stage II and III Resected Colon Cancer: Results of the Translational Study on the PETACC-3, EORTC 40993, SAKK 60-00 Trial

Arnaud Roth, Sabine Tejpar, Mauro Delorenzi et al. · Journal of Clinical Oncology · 2009 · 1.1K citations · Full text

CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer

Shuji Ogino, Katsuhiko Nosho, Gregory J. Kirkner et al. · Gut · 2008 · 777 citations · Full text

Poor Survival Associated with the <i>BRAF</i> V600E Mutation in Microsatellite-Stable Colon Cancers

Wade S. Samowitz, Carol Sweeney, Jennifer S. Herrick et al. · Cancer Research · 2005 · 742 citations

Value of Mismatch Repair, <i>KRAS</i> , and <i>BRAF</i> Mutations in Predicting Recurrence and Benefits From Chemotherapy in Colorectal Cancer

Gordon Hutchins, Katie Southward, Kelly Handley et al. · Journal of Clinical Oncology · 2011 · 675 citations · Full text