Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

Akira Kakizuka, Wilson H. Miller, Kazuhiko Umesono et al. · Cell · 1991 · 1.4K citations · Full text

Hematological Malignancy, Chromatin, Transcriptional Regulation +9

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

Hugues de Thé, Catherine Lavau, Agnès Marchio et al. · Cell · 1991 · 1.4K citations

Hematological Malignancy, Transcriptional Regulation, Pml-rarα Fusion Mrna +8

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

Gabriella D’Orazi, Barbara Cecchinelli, Tiziana Bruno et al. · Nature Cell Biology · 2001 · 673 citations

Ser 46, Signaling Pathway, Apoptosis +7

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

Thomas G. Hofmann, Andreas Möller, Hüseyin Sirma et al. · Nature Cell Biology · 2001 · 582 citations

Signal Transduction, Cell Regulation, Molecular Pathway +9

Identification of a SUMO-binding motif that recognizes SUMO-modified proteins

Jing Song, Linda K. Durrin, Thomas A. Wilkinson et al. · Proceedings of the National Academy of Sciences · 2004 · 581 citations · Full text

Reductive Stress, Protein Function, Signal Transduction +11