Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

Structure of 20S proteasome from yeast at 2.4Å resolution

M. Groll, Lars Ditzel, Jan Löwe et al. · Nature · 1997 · 2.3K citations

Life Sciences, Biochemistry, Molecular Biology +10

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

Medicine, Medicinal Chemistry, Oncology +8

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

Paolo Moi, Isadora Asunis, Antonio Cao et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations

Life Sciences, Genetics, Molecular Biology +17

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase ₁  gene

Venugopal Radjendirane, Anil K. Jaiswal · Proceedings of the National Academy of Sciences · 1996 · 1K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast

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