Cyclooxygenase active bioflavonoids from Balaton™ tart cherry and their structure activity relationships

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

Jaime L. Masferrer, Ben S. Zweifel, Pamela T. Manning et al. · Proceedings of the National Academy of Sciences · 1994 · 1.3K citations

Veterinary Medicine, Immunology, Pharmacology +17

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

Elizabeth A. Meade, William L. Smith, David L. DeWitt · Journal of Biological Chemistry · 1993 · 1.3K citations · Full text

Medicine, Biochemistry, Pharmacology +15

Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme.

Martin E. Hemler, William E.M. Lands · Journal of Biological Chemistry · 1976 · 435 citations · Full text

Life Sciences, Biochemistry, Enzymology +15

The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.

David L. DeWitt, E.A. El-Harith, Susanne A. Kraemer et al. · Journal of Biological Chemistry · 1990 · 427 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +15

Selectivity of Neutrophil 5-Lipoxygenase and Cyclo-oxygenase Inhibition by an Anti-inflammatory Flavonoid Glycoside and Related Aglycone Flavonoids

M.A. Moroney, M. José Alcaraz, Robert A. Forder et al. · Journal of Pharmacy and Pharmacology · 1988 · 325 citations

Medicine, Medicinal Chemistry, Pharmacology +15