Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genes

RAG-1-deficient mice have no mature B and T lymphocytes

Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations

Life Sciences, Genetics, Immunology +13

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Yoichi Shinkai · Cell · 1992 · 2.6K citations

Life Sciences, Genetics, Immunology +14

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

André Veillette, Michael A. Bookman, Eva Horak et al. · Cell · 1988 · 1.4K citations

Life Sciences, Immunology, Molecular Biology +14

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

Peter Mombaerts, Alan R. Clarke, Michael A. Rudnicki et al. · Nature · 1992 · 1.1K citations

Life Sciences, Genetics, Immunology +16

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

David B. Straus · Cell · 1992 · 1K citations

Life Sciences, Immunology, Molecular Biology +16