Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Erik D. Roberson, Kimberly Scearce‐Levie, Jorge J. Palop et al. · Science · 2007 · 1.9K citations

Life Sciences, Neurobiology, Neuroscience +17

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, Hoau-Yan Wang, Hala Kazi et al. · Journal of Clinical Investigation · 2012 · 1.8K citations · Full text

Medicine, Neurology, Neuroscience +17

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

Eric van Steen, Benjamin M. Terry, Enrique J. Rivera et al. · Journal of Alzheimer s Disease · 2005 · 1.7K citations

Life Sciences, Neurobiology, Neuroscience +17

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

Lauren M. Billings, Salvatore Oddo, Kim N. Green et al. · Neuron · 2005 · 1.3K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

Suzanne Craft · Archives of Neurology · 2011 · 1.2K citations

Medicine, Neurology, Neuroscience +17