Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of Midazolam

Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism

Mary F. Paine, Mehraneh Khalighi, Jeannine M. Fisher et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 792 citations

Medicine, Pharmacokinetics, Pharmacology +17

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

Thomas Kronbach, Daniel Mathys, Makoto Umeno et al. · Molecular Pharmacology · 1989 · 535 citations

Medicine, Pharmacology, Biochemical Pharmacology +15

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

Joseph C. Kolars, Phyllissa Schmiedlin‐Ren, John D. Schuetz et al. · Journal of Clinical Investigation · 1992 · 533 citations · Full text

Medicine, Molecular Biology, Pharmacology +14

Comparative Metabolic Capabilities of CYP3A4, CYP3A5, and CYP3A7

J. Andrew Williams, Barbara J. Ring, Varon E. Cantrell et al. · Drug Metabolism and Disposition · 2002 · 468 citations

Medicine, Biochemistry, Pharmacology +17

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

Klaus T. Olkkola, Janne T. Backman, Pertti J. Neuvonen · Clinical Pharmacology & Therapeutics · 1994 · 412 citations

Medicine, Pharmacokinetics, Pharmacology +14