Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors

Comparative Protein Structure Modeling Using Modeller

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Improved protein–ligand docking using GOLD

Marcel L. Verdonk, Jason C. Cole, Michael J. Hartshorn et al. · Proteins Structure Function and Bioinformatics · 2003 · 3K citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

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Life Sciences, Biochemistry, Endocrinology +14

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

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Medicine, Medicinal Chemistry, Pharmacology +13

Protein structure prediction servers at University College London

Kevin Bryson, Liam J. McGuffin, R. L. Marsden et al. · Nucleic Acids Research · 2005 · 729 citations · Full text

Life Sciences, Biochemistry, Bioinformatics +13