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Medicine, Biochemistry, Pharmacology +9

A Novel Approach to Predicting P450 Mediated Drug Metabolism. CYP2D6 Catalyzed N-Dealkylation Reactions and Qualitative Metabolite Predictions Using a Combined Protein and Pharmacophore Model for CYP2D6

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Medicine, Medicinal Chemistry, Pharmacology +17

Introduction of Metoprolol Increases Plasma B-Type Cardiac Natriuretic Peptides in Mild, Stable Heart Failure

Mark Davis, Mark Richards, M. Gary Nicholls et al. · Circulation · 2006 · 126 citations

Medicine, Cardiology, Pharmacology +10

Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol derivatives. Preparation, identification of metabolite regioisomers, and metabolism by CYP2D6.

Alana L. Upthagrove, Wendel L. Nelson · PubMed · 2001 · 41 citations

Medicine, Biochemistry, Pharmacology +17

STRUCTURAL ELUCIDATION OF HUMAN OXIDATIVE METABOLITES OF MURAGLITAZAR: USE OF MICROBIAL BIOREACTORS IN THE BIOSYNTHESIS OF METABOLITE STANDARDS

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Life Sciences, Biochemistry, Pharmacology +14