STRUCTURAL ELUCIDATION OF HUMAN OXIDATIVE METABOLITES OF MURAGLITAZAR: USE OF MICROBIAL BIOREACTORS IN THE BIOSYNTHESIS OF METABOLITE STANDARDS

Isohumulones, Bitter Acids Derived from Hops, Activate Both Peroxisome Proliferator-activated Receptor α and γ and Reduce Insulin Resistance

Hiroaki Yajima, Emiko Ikeshima, Maho Shiraki et al. · Journal of Biological Chemistry · 2004 · 160 citations · Full text

Life Sciences, Biochemistry, Endocrinology +10

Phase I and phase II enzymes produced by<i>Cunninghamella elegans</i>for the metabolism of xenobiotics

Donglu Zhang, Yifan Yang, Julian E.A. Leakey et al. · FEMS Microbiology Letters · 1996 · 109 citations

Medicine, Biochemistry, Pharmacology +17

Design and Synthesis of <i>N</i>-[(4-Methoxyphenoxy)carbonyl]-<i>N</i>-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with Efficacious Glucose and Lipid-Lowering Activities

Pratik Devasthale, Sean Chen, Yoon Jeon et al. · Journal of Medicinal Chemistry · 2004 · 108 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

IBX-Mediated Oxidation of Primary Alcohols and Aldehydes To Form Carboxylic Acids

Ralph Mazitschek, Marcel Mülbaier, Athanassios Giannis · Angewandte Chemie International Edition · 2002 · 75 citations · Full text

Natural Sciences, Chemistry, Catalysis +6

Biotransformation of amitriptyline by Cunninghamella elegans.

Dengxian Zhang, F E Evans, James P. Freeman et al. · Drug Metabolism and Disposition · 1995 · 53 citations

Life Sciences, Biochemistry, Pharmacology +9