Free iron catalyzes oxidative damage to hematopoietic cells/mesenchymal stem cells<i>in vitro</i>and suppresses hematopoiesis in iron overload patients

Abstract

Our study shows that iron overload injures the hematopoiesis by damaging hematopoietic cell and hematopoietic microenvironment, which is mediated by ROS-related signaling proteins.