Concepedia

Free iron catalyzes oxidative damage to hematopoietic cells/mesenchymal stem cells<i>in vitro</i>and suppresses hematopoiesis in iron overload patients

Wenyi Lu, Mingfeng Zhao, Sajin Rajbhandary, Fang Xie, Xiao Chai, Juan Mu, Juanxia Meng, Yong-Jun Liu, Yan Jiang, Xinnv Xu,

European Journal Of Haematology · 2013 · 86 citations · 27 references

DOIFull text

Open access

Abstract

Our study shows that iron overload injures the hematopoiesis by damaging hematopoietic cell and hematopoietic microenvironment, which is mediated by ROS-related signaling proteins.

References

27

World Health Organization Classification of Neoplastic Diseases of the Hematopoietic and Lymphoid Tissues: Report of the Clinical Advisory Committee Meeting—Airlie House, Virginia, November 1997

Nancy L. Harris, Elaine S. Jaffe, J Diébold et al. · Journal of Clinical Oncology · 1999 · 3.3K citations

Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia

Bruce D. Cheson · Blood · 2006 · 1.6K citations

FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Zuzana Tóthová, Ramya Kollipara, Brian J.P. Huntly et al. · Cell · 2007 · 1.5K citations · Full text

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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Keisuke Ito, Atsushi Hirao, Fumio Arai et al. · Nature Medicine · 2006 · 1.3K citations

, , +13

Pathology and genetics: Tumours of haematopoietic and lymphoid tissues

Paresh Vyas · The Lancet Oncology · 2001 · 988 citations

, , +4