Concepedia

Development of novel bisubstrate-type inhibitors of histone methyltransferase SET7/9

Shuichi Mori, Kenta Iwase, Naoko Iwanami, Yujiro Tanaka, Hiroyuki Kagechika, Tomoya Hirano

Bioorganic & Medicinal Chemistry · 2010 · 58 citations · 26 references

DOI

Concepts

References

26

The language of covalent histone modifications

Brian D. Strahl, C. David Allis · Nature · 2000 · 8.6K citations

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EZH2 is downstream of the pRB‐E2F pathway, essential for proliferation and amplified in cancer

Adrian P. Bracken · The EMBO Journal · 2003 · 1.2K citations · Full text

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Reversal of H3K9me2 by a Small-Molecule Inhibitor for the G9a Histone Methyltransferase

Stefan Kubicek, Roderick J. O’Sullivan, Elias August et al. · Molecular Cell · 2007 · 847 citations

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Regulation of p53 activity through lysine methylation

Sergei Chuikov, Julia K. Kurash, J. Wilson et al. · Nature · 2004 · 809 citations

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Repression of p53 activity by Smyd2-mediated methylation

Jing Huang, Laura Perez-Burgos, Brandon J. Placek et al. · Nature · 2006 · 620 citations

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