Reversible inhibition and mechanism-based irreversible inactivation of monoamine oxidases by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

J. William Langston, Philip L. Ballard, James W. Tetrud et al. · Science · 1983 · 4.9K citations

Life Sciences, Neuroscience, Pharmacology +14

Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

Harvey S. Penefsky · Journal of Biological Chemistry · 1977 · 1.6K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

Kan Chiba, Anthony J. Trevor, Neal Castagnoli · Biochemical and Biophysical Research Communications · 1984 · 1.1K citations

Life Sciences, Neuroscience, Pharmacology +14

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

J. William Langston, Ian Irwin, Elizabeth B. Langston et al. · Science · 1984 · 583 citations

Medicine, Neuroscience, Pharmacology +17

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

J. William Langston, Ian Irwin, Elizabeth B. Langston et al. · Neuroscience Letters · 1984 · 432 citations

Pharmacy, Pharmacology, Toxicology +15