Ian Irwin

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

J. William Langston, Philip L. Ballard, James W. Tetrud et al. · Science · 1983 · 4.9K citations

Life Sciences, Neuroscience, Pharmacology +14

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

J. William Langston, Lysia S. Forno, Charles S. Rebert et al. · Brain Research · 1984 · 919 citations

Medicine, Pharmacology, Toxicology +5

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

J. William Langston, Ian Irwin, Elizabeth B. Langston et al. · Science · 1984 · 583 citations

Medicine, Neuroscience, Pharmacology +17

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

J. William Langston, Ian Irwin, Elizabeth B. Langston et al. · Neuroscience Letters · 1984 · 432 citations

Pharmacy, Pharmacology, Toxicology +15

Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

Lysia S. Forno, J. William Langston, Louis E. DeLanney et al. · Annals of Neurology · 1986 · 348 citations

Life Sciences, Neurology, Neuroscience +14