1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

J. William Langston, Philip L. Ballard, James W. Tetrud et al. · Science · 1983 · 4.9K citations

Life Sciences, Neuroscience, Pharmacology +14

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Richard S. Burns, Chuang C. Chiueh, Sanford P. Markey et al. · Proceedings of the National Academy of Sciences · 1983 · 2.1K citations · Full text

Medicine, Neuroscience, Pharmacology +17

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

J. William Langston, Lysia S. Forno, Charles S. Rebert et al. · Brain Research · 1984 · 919 citations

Medicine, Pharmacology, Toxicology +5

Isolation and Identification of Drugs

Keith Simpson · Journal of Clinical Pathology · 1970 · 512 citations · Full text

Pharmacy, Pharmaceutical Analysis, Pharmacology +10

AETIOLOGY OF PARKINSON'S DISEASE

DonaldB. Calne, J. William Langston · The Lancet · 1983 · 466 citations

Medicine, Neurology, Neuroscience +12