Sir Isaac Newton, sepsis, SIRS, and CARS

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

René de Waal Malefyt, John B.A.G. Haanen, Hergen Spits et al. · The Journal of Experimental Medicine · 1991 · 1.9K citations · Full text

Life Sciences, Cell Biology, Immunology +15

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

Elizabeth Ziegler, Charles J. Fisher, Charles L. Sprung et al. · New England Journal of Medicine · 1991 · 1.6K citations · Full text

Veterinary Medicine, Immunology, Pharmacotherapy +17

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

Charles J. Fisher · JAMA · 1994 · 932 citations

Veterinary Medicine, Immunology, Pharmacotherapy +8

Serum Cytokine Levels in Human Septic Shock

Michael R. Pinsky, Jean‐Louis Vincent, Jacques Devière et al. · CHEST Journal · 1993 · 888 citations

Veterinary Medicine, Immunology, Pathobiology +14

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome

Edward Abraham · JAMA · 1995 · 834 citations

Veterinary Medicine, Pharmacology, Pharmacotherapy +15