Concepedia

Mice engineered for an obligatory Mdm4 exon skipping express higher levels of the Mdm4-S isoform but exhibit increased p53 activity

Boris Bardot, Rachida Bouarich-Bourimi, Julia Leemput, Vincent Lejour, Annaïg Hamon, L Plancke, Aart G. Jochemsen, Iva Simeonova, Ming Fang, Franck Toledo

Oncogene · 2014 · 35 citations · 32 references

DOI

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References

32

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

Scott W. Lowe, H. Earl Ruley, Tyler Jacks et al. · Cell · 1993 · 2.9K citations

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Inactivation of the p53 pathway in retinoblastoma

Nikia A. Laurie, Stacy L. Donovan, Chie‐Schin Shih et al. · Nature · 2006 · 587 citations

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

John M. Parant, Arturo Chávez‐Reyes, Natalie A Little et al. · Nature Genetics · 2001 · 515 citations

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Regulation of constitutive and alternative splicing by PRMT5 reveals a role for <i>Mdm4</i> pre-mRNA in sensing defects in the spliceosomal machinery

Marco Bezzi, Shun Xie Teo, Julius Müller et al. · Genes & Development · 2013 · 318 citations · Full text

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Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development

Domenico Migliorini, Eros Lazzerini Denchi, Davide Danovi et al. · Molecular and Cellular Biology · 2002 · 310 citations · Full text

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