Mutations in NS5B Polymerase of Hepatitis C Virus: Impacts on in Vitro Enzymatic Activity and Viral RNA Replication in the Subgenomic Replicon Cell Culture

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

Qui‐Lim Choo, George Kuo, Amy J. Weiner et al. · Science · 1989 · 6.9K citations

Life Sciences, Genetics, Molecular Biology +13

Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

Volker Lohmann, Frank Körner, Jan Oliver Koch et al. · Science · 1999 · 2.8K citations

Life Sciences, Microbiology, Molecular Biology +16

Efficient Initiation of HCV RNA Replication in Cell Culture

Keril J. Blight, Alexander A. Kolykhalov, Charles M. Rice · Science · 2000 · 1.4K citations

Life Sciences, Microbiology, Molecular Biology +16

Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

Izumu Saito, Tatsuo Miyamura, Akira Ohbayashi et al. · Proceedings of the National Academy of Sciences · 1990 · 1.1K citations

Medicine, Infectious Diseases, Oncology +17

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site.

Patricia C Weber, Charles A. Lesburg, Michael Cable et al. · Nature Structural Biology · 1999 · 732 citations

Life Sciences, Biochemistry, Molecular Biology +17