Coexpression of hyperactivated AKT1 with additional genes activated in leukemia drives hematopoietic progenitor cells to cell cycle block and apoptosis

High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers

Yardena Samuels, Zhenghe Wang, Alberto Bardelli et al. · Science · 2004 · 3.4K citations

Medicine, Genetics, Oncology +11

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

John D. Carpten, Andrew L. Faber, Candice L. Horn et al. · Nature · 2007 · 1.3K citations

Medicine, Molecular Biology, Oncology +12

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

Véronique Nogueira, Youngkyu Park, Chia-Chen Chen et al. · Cancer Cell · 2008 · 769 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

Aimee D. Kohn, Fumito Takeuchi, Richard A. Roth · Journal of Biological Chemistry · 1996 · 474 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Pengda Liu, Michael J. Begley, Wojciech Michowski et al. · Nature · 2014 · 367 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16