Concepedia

Gram-Scale Synthesis of (+)-Discodermolide

Amos B. Smith, Michael D. Kaufman, Thomas J. Beauchamp, Matthew J. LaMarche, Hirokazu Arimoto

Organic Letters · 1999 · 121 citations · 20 references

DOI

Concepts

Abstract

[formula: see text] A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale.

References

20

Promotion of microtubule assembly in vitro by taxol

Peter B. Schiff, Jane Fant, Susan Band Horwitz · Nature · 1979 · 3.6K citations

, , +9

A useful 12-I-5 triacetoxyperiodinane (the Dess-Martin periodinane) for the selective oxidation of primary or secondary alcohols and a variety of related 12-I-5 species

D. B. DESS, J. C. Martin · Journal of the American Chemical Society · 1991 · 2.1K citations

, , +8

Activated Dimethyl Sulfoxide: Useful Reagents for Synthesis

Anthony J. Mancuso, Daniel Swern · Synthesis · 1981 · 1.2K citations

, , +2

Sulfur trioxide in the oxidation of alcohols by dimethyl sulfoxide

Jekishan R. Parikh, W. von E. Doering · Journal of the American Chemical Society · 1967 · 1K citations

, , +6

Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol<sup>,</sup>

Ernst ter Haar, Richard Kowalski, Ernest Hamel et al. · Biochemistry · 1996 · 381 citations

, , +17