Concepedia

Melanocortins Mimic the Effects of Leptin to Restore Reproductive Function in Lean Hypogonadotropic Ewes

Kathryn Backholer, Marissa A. Bowden, Kevin Gamber, Christian Bjørbæk, Javed Iqbal, Iain J. Clarke

Neuroendocrinology · 2009 · 57 citations · 55 references

DOIFull text

Open access

Abstract

Leptin corrects the hypogonadotropic state in the lean condition by upregulation of POMC gene expression, and may increase transport and acetylation of melanocortins to target cells in the brain. Melanocortin treatment restores LH secretion in lean animals.

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