A diastereoselective synthesis of pseudo-C2 -symmetric 1,3-diamino-2-propanols as core units in HIV protease inhibitors

Rational Design of Peptide-Based HIV Proteinase Inhibitors

Noel A. Roberts, Joseph A. Martin, Derek Kinchington et al. · Science · 1990 · 925 citations

Life Sciences, Biochemistry, Medicinal Chemistry +17

Design, Activity, and 2.8 Å Crystal Structure of a <i>C</i> ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

John W. Erickson, David J. Neidhart, John H. VanDrie et al. · Science · 1990 · 528 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation

T. J. MCQUADE, A G Tomasselli, L Liu et al. · Science · 1990 · 377 citations

Life Sciences, Biochemistry, Molecular Biology +17

A mild two-step method for the hydrolysis of lactams and secondary amides

Daniel L. Flynn, Robert E. Zelle, Paul A. Grieco · The Journal of Organic Chemistry · 1983 · 272 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

Structure-based, C2 symmetric inhibitors of HIV protease

Dale J. Kempf, Daniel W. Norbeck, LynnMarie Codacovi et al. · Journal of Medicinal Chemistry · 1990 · 211 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13