Generation of novel radiolabeled opiates through site-selective iodination

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse Brain

Avram Goldstein, Louise I. Lowney, B K Pal · Proceedings of the National Academy of Sciences · 1971 · 413 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Classification of multiple morphine and enkephalin binding sites in the central nervous system.

Benjamin Wolozin, Gavril W. Pasternak · Proceedings of the National Academy of Sciences · 1981 · 372 citations

Medicine, Pharmacokinetics, Pharmacology +16

Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype.

J A Clark, L Liu, MA Price et al. · Journal of Pharmacology and Experimental Therapeutics · 1989 · 339 citations

Medicine, Neuroscience, Pharmacology +17

Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors.

R. Suzanne Zukin, M Eghbali, David L. Olive et al. · Proceedings of the National Academy of Sciences · 1988 · 315 citations

Medicine, Neurobiology, Pharmacology +13