Concepedia

Mu opioid receptor knockdown in the substantia nigra/ventral tegmental area by synthetic small interfering RNA blocks the rewarding and locomotor effects of heroin

Yong Zhang, Markus Landthaler, Stefan D. Schlussman, Vadim Yuferov, A. Ho, Thomas Tuschl, Mary Jeanne Kreek

Neuroscience · 2008 · 96 citations · 35 references

DOI

Concepts

References

35

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

, , +17

mouse brain in stereotaxic coordinates

Keith B.J. Franklin, George Paxinos · 1997 · 3.1K citations

, , +9

Rational siRNA design for RNA interference

Angela Reynolds, Devin Leake, Queta Boese et al. · Nature Biotechnology · 2004 · 2.1K citations

, , +12

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

, , +17

Opioids excite dopamine neurons by hyperpolarization of local interneurons

SW Johnson, RA North · Journal of Neuroscience · 1992 · 1.6K citations · Full text

, , +17