Improved Synthesis of Anhydrohexitol Building Blocks for Oligonucleotide Synthesis

Abstract

Abstract The synthesis of the four building blocks used for the preparation of hexitol nucleic acids were optimized. The nucleoside analogues with a purine base moiety are best prepared by a nucleophilic substitution reaction, whereas the pyrimidine nucleosides can best be obtained using Mitsunobu‐type conditions.