Enhanced Rap1 Activation and Insulin Secretagogue Properties of an Acetoxymethyl Ester of an Epac-selective Cyclic AMP Analog in Rat INS-1 Cells

Specificity and mechanism of action of some commonly used protein kinase inhibitors

Stephen Davies, Helen Reddy, Matilde Caivano et al. · Biochemical Journal · 2000 · 4.1K citations · Full text

Drug Target, Pharmacotherapy, Pharmaceutical Chemistry +17

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

Johan de Rooij, Fried Zwartkruis, Mark H. G. Verheijen et al. · Nature · 1998 · 2K citations

Signal Transduction, Molecular Physiology, Biochemistry +7

A Family of cAMP-Binding Proteins That Directly Activate Rap1

Hiroaki Kawasaki, Gregory M. Springett, Naoki Mochizuki et al. · Science · 1998 · 1.4K citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

Mark Vossler, Hong Yao, Randall D. York et al. · Cell · 1997 · 1.1K citations · Full text

Rap1-dependent Pathway, Signal Transduction, Signaling Pathway +11

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

Jorrit M. Enserink, Anne Elisabeth Christensen, Johan de Rooij et al. · Nature Cell Biology · 2002 · 690 citations

Signal Transduction, Signaling Pathway, Cell Regulation +10