Lipidic nucleic acids

Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation.

Tula Saison‐Behmoaras, Bruno Tocqué, Ignacio Antonio Gemio del Rey et al. · The EMBO Journal · 1991 · 203 citations · Full text

Selective Cleavage, Immunology, Oligonucleotide +7

Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution

P.C. de Smidt, Trung Le Doan, Sandro De Falco et al. · Nucleic Acids Research · 1991 · 152 citations · Full text

Immunology, Pathology, Cell Death +19

Synthesis of alkylating oligonucleotide derivatives containing cholesterol or phenazinium residues at their 3′‐terminus and their interaction with DNA within mammalian cells

A.S. Boutorin, L.V. Gus'kova, N.D. Kobetz et al. · FEBS Letters · 1989 · 149 citations · Full text

Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates

Regan G. Shea, James C. Marsters, Norbert Bischofberger · Nucleic Acids Research · 1990 · 140 citations · Full text

Viral Replication, Biochemistry, Hybridization Properties +13

Synthesis and physical properties of<i>anti</i>-HIV antisense oligonucleotides bearing terminal lipophilic groups

Calum MacKellar, Duncan Graham, David W. Will et al. · Nucleic Acids Research · 1992 · 132 citations · Full text