Concepedia

A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies

Takayuki Ikezoe, Jing Yang, Chie Nishioka, Yuka Takezaki, Taizo Tasaka, Kazuto Togitani, H. Phillip Koeffler, Akihito Yokoyama

Leukemia · 2009 · 71 citations · 29 references

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29

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials

Panagiotis Kottaridis, Rosemary E. Gale, Marion E. Frew et al. · Blood · 2001 · 1.5K citations · Full text

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Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

Heidi A. Lane, Erich A. Nigg · The Journal of Cell Biology · 1996 · 690 citations · Full text

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Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

Roy M. Golsteyn, Kirsten Mundt, Andrew M. Fry et al. · The Journal of Cell Biology · 1995 · 479 citations · Full text

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The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

Hiroyuki Ohkura, Iain Hagan, David M. Glover · Genes & Development · 1995 · 373 citations · Full text

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Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer

G Wolf, Robert Elez, A Doermer et al. · Oncogene · 1997 · 326 citations

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