AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo

Jing Yang, Takayuki Ikezoe, Chie Nishioka, +9

Blood

Isolation and partial characterization of a noval amino sugar-containing fucan sulfate from commercial Fucus vesiculosus fucoidan

Takashi Nishino, Chie Nishioka, Hiroaki Ura, +1

Carbohydrate Research

BiochemistryGlycobiologyBiotechnologyPartial CharacterizationPolysaccharide +5

A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia

Takayuki Ikezoe, Jing Yang, Chie Nishioka, +8

Molecular Cancer Therapeutics

Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells

Takayuki Ikezoe, Chie Nishioka, Kentaro Bandobashi, +6

Leukemia Research

Signal TransductionSignaling PathwayCell RegulationReceptor Tyrosine KinaseLongitudinal Inhibition +7

The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling

Takayuki Ikezoe, Chie Nishioka, Taizo Tasaka, +5

Molecular Cancer Therapeutics

Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells

Chie Nishioka, Takayuki Ikezoe, Jun‐Yi Yang, +2

Leukemia

Histone ModificationsChromatinHematological MalignancyHistone Deacetylase InhibitorMixed-phenotype Acute Leukemia +7

MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells

Chie Nishioka, Takayuki Ikezoe, Jing Yang, +3

Leukemia Research

Histone ModificationsChromatinChaperone FunctionChromatin RemodelingMolecular Biology +6

A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies

Takayuki Ikezoe, Jing Yang, Chie Nishioka, +5

Leukemia

Hematological MalignancyNovel Treatment StrategyMedicineMalignant Blood DisorderReceptor Tyrosine Kinase +7

NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines

Yang Yang, Takayuki Ikezoe, Chie Nishioka, +7

British Journal of Cancer

Downregulation of miR‐217 correlates with resistance of ph⁺ leukemia cells to <scp>ABL</scp> tyrosine kinase inhibitors

Chie Nishioka, Takayuki Ikezoe, Jing Yang, +3

Cancer Science