Identification of the Nrf2–Keap1 pathway in the European eel Anguilla anguilla: Role for a transcriptional regulation of antioxidant genes in aquatic organisms

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

Paolo Moi, Isadora Asunis, Antonio Cao et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations · Full text

Recognition Site Probe, Molecular Regulation, Genetics +18

Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

The cytoprotective role of the Keap1–Nrf2 pathway

Liam Baird, Albena T. Dinkova‐Kostova · Archives of Toxicology · 2011 · 1K citations

Signal Transduction, Molecular Pathway, Cell Death +5

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Nobunao Wakabayashi, Albena T. Dinkova‐Kostova, W. David Holtzclaw et al. · Proceedings of the National Academy of Sciences · 2004 · 959 citations · Full text

Molecular Biology, Redox Biology, Oxidant Stress +19

Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms

Francesco Regoli, Maria Elisa Giuliani · Marine Environmental Research · 2013 · 912 citations

Biology, Engineering, Biochemistry +14