The First Synthesis of a Thioglycoside Analogue of the Immunostimulant KRN7000

Abstract

The first total synthesis of a thioglycoside analogue of KRN7000, a potential immunostimulant, is described. Two key intermediates are alpha-galactosyl thiol 4 and phytosphingosine derivative 5, which were both prepared from D-galactose.