Aggregation Kinetics of Interrupted Polyglutamine Peptides

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Montserrat Arrasate, Siddhartha Mitra, Erik S. Schweitzer et al. · Nature · 2004 · 2K citations

Life Sciences, Neurobiology, Neuroscience +15

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases.

M. F. Perutz, T. Johnson, Masashi Suzuki et al. · Proceedings of the National Academy of Sciences · 1994 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +17

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

Songming Chen, Frank A. Ferrone, Ronald Wetzel · Proceedings of the National Academy of Sciences · 2002 · 527 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Amyloid fibers are water-filled nanotubes

M. F. Perutz, J.T. Finch, John Berriman et al. · Proceedings of the National Academy of Sciences · 2002 · 508 citations

Life Sciences, Biology, Molecular Biology +16

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

Nihar Ranjan Jana · Human Molecular Genetics · 2000 · 438 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17