Enzyme‐Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose

Andrea Bernardos, Elena Aznar, M. Dolores Marcos, Ramón Martínez‐Máñez, Félix Sancenón, Juán Soto, José Manuel Barat Baviera, Pedro Amorós

Angewandte Chemie International Edition · 2009 · 249 citations · 39 references

Concepts

Abstract

The great escape: A biocontrolled gated material has been prepared by grafting a lactose derivative onto the pore outlets of a mesoporous support. The galactosidase-induced hydrolysis of the β1→4 glycosidic bond in the lactose moiety (red box in picture) allows the release of a dye entrapped in the pores of the hybrid material to the bulk solution.

References

39