RENAL XENOGRAFTS FROM TRIPLE-TRANSGENIC PIGS ARE NOT HYPERACUTELY REJECTED BUT CAUSE COAGULOPATHY IN NON-IMMUNOSUPPRESSED BABOONS

Abstract

Strong expression of CD55 and CD59 completely protected porcine kidneys from hyperacute rejection and allowed a detailed analysis of xenograft rejection in the absence of immunosuppression. Coagulopathy appears to be a common feature of pig-to-baboon renal transplantation and represents yet another major barrier to its clinical application.