Science Translational Medicine · 2014 · 267 citations · 24 references
MedicineMolecular BiologyOncologyGene TherapyMolecular OncologyPrecision OncologyNoncoding Rna In CancerRna InterferenceSmall Interfering Rna BiologyCancer Patient ManagementNoncoding Rna TherapeuticsRna Interference TherapeuticsShort Interfering Rna TherapySmall Interfering Rna (Sirna) ChemistrySmall Interfering Rna (Sirna) PathwaysSmall Interfering Rna FunctionTherapeutic Small Interfering Rna
RNA interference (RNAi) therapy is a rapidly emerging platform for personalized cancer treatment. Recent advances in small interfering RNA delivery and target selection provide unprecedented opportunities for clinical translation. Here, we discuss these advances and present strategies for making RNAi-based therapy a viable part of cancer management.
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