Concepedia

Stereocontrolled Total Synthesis of (+)-Vinblastine

Satoshi Yokoshima, Toshihiro Ueda, Satoshi Kobayashi, Ayato Sato, Takeshi Kuboyama, Hidetoshi Tokuyama, Tohru Fukuyama

Journal of the American Chemical Society · 2002 · 241 citations · 13 references

DOI

Concepts

Abstract

A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.

References

13

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Total synthesis of (+)-calyculin A

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Dibutyltin Oxide Catalyzed Selective Sulfonylation of α-Chelatable Primary Alcohols

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Alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don.) V.**Organic Chemical Development and Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Ind.

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