Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela et al. · Nature · 2006 · 2.6K citations

Life Sciences, Immunology, Infectious Diseases +17

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

Allan Zajac, Joseph N. Blattman, Kaja Murali‐Krishna et al. · The Journal of Experimental Medicine · 1998 · 2K citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

E. John Wherry, Joseph N. Blattman, Kaja Murali‐Krishna et al. · Journal of Virology · 2003 · 1.6K citations

Life Sciences, Immunology, Infectious Diseases +17

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

Victor Appay, P. Rod Dunbar, Margaret Callan et al. · Nature Medicine · 2002 · 1.6K citations

Life Sciences, Immunology, Microbiology +16

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

Lydie Trautmann, Loury Janbazian, Nicolas Chomont et al. · Nature Medicine · 2006 · 1.5K citations

Life Sciences, Immunology, Infectious Diseases +17