A three-step synthesis of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

J. Jean Cui, Michelle Tran‐Dubé, Hong Shen et al. · Journal of Medicinal Chemistry · 2011 · 922 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms

Helen Y. Zou, Qiuhua Li, Joseph H. Lee et al. · Cancer Research · 2007 · 750 citations · Full text

Medicine, Medicinal Chemistry, Oncology +16

Fit-for-Purpose Development of the Enabling Route to Crizotinib (PF-02341066)

Pieter D. de Koning, Douglas McAndrew, Robert Moore et al. · Organic Process Research & Development · 2011 · 89 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Synthesis and Structure−Affinity Relationships of Novel Dibenzylideneacetone Derivatives as Probes for β-Amyloid Plaques

Mengchao Cui, Masahiro Ono, Hiroyuki Kimura et al. · Journal of Medicinal Chemistry · 2011 · 75 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Halogenation of Pyrazoles Using <i>N</i>‐Halosuccinimides in CCl₄ and in Water

Zhigang Zhao, Zhong‐Xia Wang · Synthetic Communications · 2007 · 60 citations

Natural Sciences, Chemistry, Catalysis +6