A novel guanine N3 alkylation by antitumor antibiotic duocarmycin A

Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro.

John M. Essigmann, Robert G. Croy, Alex M. Nadzan et al. · Proceedings of the National Academy of Sciences · 1977 · 508 citations · Full text

Pharmacy, Biochemistry, Toxicology +17

Reaction of the Antitumor Antibiotic CC-1065 with DNA: Structure of a DNA Adduct with DNA Sequence Specificity

Laurence H. Hurley, Vincent L. Reynolds, David H. Swenson et al. · Science · 1984 · 204 citations

Life Sciences, Molecular Biology, Pharmacology +17

Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophore

Dale L. Boger, Takayoshi Ishizaki, Hamideh Zarrinmayeh et al. · Journal of the American Chemical Society · 1990 · 136 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Covalent binding of antitumor antibiotics in the minor groove of DNA. Mechanism of action of CC-1065 and the pyrrolo(1,4)benzodiazepines

Laurence H. Hurley, Donald R. VanDevanter · Accounts of Chemical Research · 1986 · 124 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Sequence specificity of DNA alkylation by the unnatural enantiomer of CC-1065 and its synthetic analogs

Laurence H. Hurley, Martha A. Warpehoski, Chong Soon Lee et al. · Journal of the American Chemical Society · 1990 · 106 citations

Pharmacy, Chemistry, Molecular Biology +7