Preparation of mappicine ketones from camptothecins: Chemistry of the camptothecin E ring

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations

Medicine, Medicinal Chemistry, Pharmacology +8

Studies on the Antitumor Activity, Mechanism of Action, and Cell Cycle Effects of Camptothecin

Robert C. Gallo, Jacqueline Whang‐Peng, Richard H. Adamson · JNCI Journal of the National Cancer Institute · 1971 · 216 citations

Medicine, Oncology, Pharmacology +14

The chemical rearrangement of camptothecin to mappicine ketone

William D. Kingsbury · Tetrahedron Letters · 1988 · 22 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10