IL-23 neutralization protects mice from Gram-negative endotoxic shock

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Jonathan Sherlock, Yi Chen, Craig A. Murphy et al. · Nature · 2003 · 2.9K citations

Life Sciences, Immunology, Neuroscience +14

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

Birgit Oppmann, Robin Lesley, Bianca Blom et al. · Immunity · 2000 · 2.8K citations · Full text

Life Sciences, Immunology, Cell Signaling +9

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

Sudeepta Aggarwal, Nico Ghilardi, Ming-Hong Xie et al. · Journal of Biological Chemistry · 2003 · 1.8K citations · Full text

Life Sciences, Cell Biology, Immunology +10

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

Craig A. Murphy, Claire L. Langrish, Yi Chen et al. · The Journal of Experimental Medicine · 2003 · 1.6K citations · Full text

Medicine, Immunology, Pathology +17

Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense

Peng Ye, Fred H. Rodriguez, Suzanne T. Kanaly et al. · The Journal of Experimental Medicine · 2001 · 1.5K citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17