Concepedia

NO restores HIF-1α hydroxylation during hypoxia: Role of reactive oxygen species

Melvin Callapina, Jie Zhou, Tobias Schmid, Roman Köhl, Bernhard Brüne

Free Radical Biology and Medicine · 2005 · 115 citations · 49 references

DOI

Concepts

References

49

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

Jo A. Forsythe, Bing‐Hua Jiang, Narayan V. Iyer et al. · Molecular and Cellular Biology · 1996 · 4K citations · Full text

, , +15

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

, , +9

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

Richard K. Bruick, Steven L. McKnight · Science · 2001 · 2.5K citations

, , +16